B-spline snakes in two stages

In using Snake algorithms, the slow convergence speed is due to the large number of control points to be selected, as well as difficulties in setting the weighting factors that comprise the internal energies of the curve. Even in using the B-Spline snakes, splines cannot be fitted into the corner of the object completely. In this paper, a novel two-stage method based on B-Spline Snakes is proposed. It is superior both in accuracy and fast convergence speed over previous B-Spline Snakes. The first stage reduces the number of control points using potential function V(x,y) minimization. Hence, it allows the spline to quickly approach the minimum energy state. The second stage is designed to refine the B-Spline snakes based on the node points of the polynomials without knots. In other words, an elasticity spline is controlled by node points where knots are fixed. Simulation and validation of results are presented. Compared to the traditional B-Spline snakes, better performance was achieved using the method proposed in this paper.published_or_final_versio

Estimation of the gray level variations in soft and hard peri-implant tissue from X-ray images

In the treatment and assessment of periodontal disease periapical films are taken at regular intervals. The films are compared around the region of the implant to monitor the changes that have taken place. A computer-assisted method to automate this process is presented here. To compare two images, a pair of X-ray images are superimposed on top of each other. The images are normalized and transformed to obtain the best fit. These images are subtracted and the difference in pixel values are used as a basis for analysis. A method for improving the alignment accuracy and contrast compensation is highlighted.published_or_final_versio

Image registration in intra-oral radiography

Image registration is one of the image processing methods which is widely used in computer vision, pattern recognition, and medical imaging. In digital subtraction radiography, image registration is one of the important prerequisites to match the reference and subsequent images. In this paper, we propose an automatic non-rigid registration method namely curvature-based registration that relies on a curvature based penalizing term and its application on dental radiography. The regularizing term of this intensity-based registration approach provides affine linear transformation so that pre-registration step is no longer necessary. This leads to faster and more reliable solutions. The implementation of this approach is based on the numerical solution of the underlying Euler-Lagrange equations. In addition, a comparison between this algorithm and Linear Alignment Method (LAM) with 20 image pairs is presented. © 2005 IEEE.published_or_final_versio

Brain tumor boundary detection in MR image with generalized fuzzy operator

Boundary detection in MR image with brain tumor is an important image processing technique applied in radiology for 3D reconstruction. The nonhomogeneities density tissue of the brain with tumor can result in achieving the inaccurate location in any boundary detection algorithms. Recently, some studies using the contour deformable model with regional base technique, the performance is insufficient to obtain the fine edge in the tumor, and the considerable error in accuracy is existed. Moreover, even in some of the normal tissue region, edge created by this method has also been encompassed. In this paper, we propose a new approach to detect the boundary of brain tumor based on the generalized fuzzy operator (GFO). One typical example is used for evaluating this method with the contour deformable model.published_or_final_versio

Alternatives to colonoscopy for population-wide colorectal cancer screening

published_or_final_versio

Evaluation of the string test for the detection of Helicobacter pylori

Aim: Helicobacter pylori can be diagnosed by invasive or non-invasive tests but to obtain bacteria for culture and antibiotic susceptibility testing, an upper GI endoscopy is often required. The string test may be a minimally-invasive alternative method of obtaining H. pylori samples. This study evaluates the sensitivity and specificity of the string test in the diagnosis of H. pylori in comparison with endoscopic means of diagnosis. Methods: This was a prospective open comparative study of patients with dyspepsia with endoscopy-based tests as gold standard (defined as a positive CLO test and antral histology). Fasting patients swallowed the encapsulated-string (Entero-test Hp), which was withdrawn after 1 hour. The gastric juice from the string was plated onto H. pylori-selective media for culture. Helicobacter pylori was identified by typical colony morphology, gram stain and biochemical test results. Results: Thirty dyspeptic patients were recruited of whom 21 (70 %) were positive for H. pylori according to the gold standard. The sensitivity, specificity, positive predictive value, and negative predictive value for the string test were 38 %, 100 %, 100 % and 41 % respectively, and for endoscopic biopsies 81 %, 100 %, 100 %, 69 % respectively (P=0.004). Logistic regression showed that only abundant growth density from endoscopic biopsy cultures to be a predictor of a positive string test (P=0.018). Conclusion: The string test is an alternative method to endoscopy in obtaining H. pylori but has a low sensitivity compared to endoscopic biopsies.published_or_final_versio

Age-period-cohort analysis of tuberculosis notifications in Hong Kong from 1961 to 2005

Background: Despite its wealth, excellent vital indices and robust health care infrastructure, Hong Kong has a relatively high incidence of tuberculosis (TB) (85.4 per 100 000). Hong Kong residents have also experienced a very rapid and recent epidemiological transition; the population largely originated from migration by southern Chinese in the mid 20th century. Given the potentially long latency period of TB infection, an investigation was undertaken to determine the extent to which TB incidence rates reflect the population history and the impact of public health interventions. Methods: An age-period-cohort model was used to break down the Hong Kong TB notification rates from 1961 to 2005 into the effects of age, calendar period and birth cohort. Results: Analysis by age showed a consistent pattern across all the cohorts by year of birth, with a peak in the relative risk of TB at 20-24 years of age. Analysis by year of birth showed an increase in the relative risk of TB from 1880 to 1900, stable risk until 1910, then a linear rate of decline from 1910 with an inflection point at 1990 for a steeper rate of decline. Period effects yielded only one inflection during the calendar years 1971-5. Conclusions: Economic development, social change and the World Health Organisation's short-course directly observed therapy (DOTS) strategy have contributed to TB control in Hong Kong. The linear cohort effect until 1990 suggests that a relatively high, but slowly falling, incidence of TB in Hong Kong will continue into the next few decades.published_or_final_versio

Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes

Pregestational diabetes is highly associated with increased risk of birth defects. However, factors that can increase or reduce expressivity and penetrance of malformations in diabetic pregnancies remain poorly identified. All-trans retinoic acid (RA) plays crucial roles in embryogenesis. Here, we find that Cyp26a1, which encodes a key enzyme for catabolic inactivation of RA required for tight control of local RA concentrations, is significantly down-regulated in embryos of diabetic mice. Embryonic tissues expressing Cyp26a1 show reduced efficiency of RA clearance. Diabetes-exposed embryos are thus sensitized to RA and more vulnerable to the deleterious effects of increased RA signalling. Susceptibility to RA teratogenesis is further potentiated in embryos with a pre-existing genetic defect of RA metabolism. Increasing RA clearance efficiency by a pre-conditioning approach can counteract the increased susceptibility to RA teratogenesis in embryos of diabetic mice. Our findings provide new insight into gene-environment interactions that influence individual risk in manifestation of diabetes-related birth defects, and shed light on the environmental risk factors and genetic variants for a stratified medicine approach to screen diabetic women of childbearing age and assess risk of birth defects during pregnancy

Thyroid cancer cells boundary location by a fuzzy edge detection method

Morphometric assessment of tumor cells is important in the prediction of biological behavior of thyroid cancer. In order to automate the process, the computer-based system has to recognize the boundary of the cells. Many methods for the boundary detection have appeared in the literature and some of them applied to microscopic slice analysis. However, there is no reliable method since the gray-levels in the nuclei are uneven and are similar to the background. In the paper, a fuzzy edge detection method is used and is based on an improved generalized fuzzy operator. The method enhances the nuclei and effectively separates the cells from the background.published_or_final_versio

香港結核病患者的特徵與治療結果

OBJECTIVES: To identify the general characteristics of patients with tuberculosis, and to evaluate their treatment outcomes. DESIGN: Retrospective study. SETTING: Tuberculosis and Chest Service, Department of Health, Hong Kong. SUBJECTS AND METHODS: All patients with tuberculosis registered for treatment from 1 January 1996 to 31 December 1996 were included in the study. Information was extracted from their medical records at treatment commencement and at 12 and 24 months after treatment was instigated. Data gathered included demographic data, past treatment, site of disease, case category, treatment regimen, bacteriological status, and treatment outcome. RESULTS: There were 5757 patients for analysis. Approximately one third of patients were aged 60 years or older, and 69.1% were male. Pulmonary disease alone occurred in 77.7% of patients, while both pulmonary and extrapulmonary diseases occurred in 8.6%. New patients comprised 84.6% of cases, and 16.3% had concomitant illnesses. There was excess risk of disease among patients who were male, elderly, or who had silicosis. Only 0.1% of patients were co-infected with human immunodeficiency virus infection. Among the 5757 cases evaluated, 1324 (23.0%) were new patients with a positive sputum smear, 299 (5.2%) were patients who were retreated with a positive sputum smear, and 4134 (71.8%) were new or retreatment patients with a negative sputum smear. The overall treatment completion rates at 12 and 24 months were 80.4% and 84.8%, respectively. Males and patients aged 60 years or older had lower treatment completion rates. Non-adherence, transfer to other services, and mortality among the elderly were key factors influencing treatment outcomes. Co-morbidity was associated with better case-holding, and this more than compensated for its effect on prolongation of treatment and mortality. CONCLUSIONS: There was an excess risk of tuberculosis among male and elderly patients, who also had a less favourable outcome. Active screening of clearly identified risk groups may be appropriate but requires the completion of more in-depth studies and careful cost-effectiveness analyses. Further efforts with respect to case-holding are indicated to address treatment defaulting and transfer rates.published_or_final_versio